Chuck Lorre slams Romney, GOP with “Big Bang Theory” vanity card

























(Please note profanity in second-to-last paragraph))


LOS ANGELES (TheWrap.com) – That Chuck Lorre – what a card.





















No, seriously; what a card.


The “Big Bang Theory” and “Two and a Half Men” honcho – who’s used the vanity cards at the end of his shows to expound on everything from former “Men” star Charlie Sheen to the humilities of aging – used Thursday night’s “Big Bang Theory” card to rant about presidential candidate Mitt Romney and the current state of the Republican party.


Unfortunately for fans of political mud-flinging, the card never made it to air. Lorre published the card on his website instead, noting that he’d opted for self-censorship.


“I’ve decided to save everybody a lot of unhappiness and not submit this week’s vanity card to the CBS censors (I know when I’ve crossed the line with these things and don’t need a bunch of corporate lawyers getting their cotton blend panties in a bunch),” Lorre wrote.


Kind of a shame, really, because it’s quite a doozy.


The card takes shots at GOP politicians’ recent stances on everything from rape to FEMA, along with a dig at the reality series “The Bachelor” and a not-so-veiled reference to Romney’s Mormonism.


The card ends with a wholesale condemnation of modern American society.


The text of the vanity card is presented below in its entirety, to preserve flavor and flow:


CHUCK LORRE PRODUCTIONS, #397


CENSORED BY ME


What does it say about us when we are simultaneously pro-life and pro AK-47′s? What does it say about us when God’s will would allow a rapist to ask for shared custody and child support payments? What does it say about us when a black guy’s in charge and we say things like “it’s time to take America back”? What does it say about us when we think the institution of marriage is threatened by gay people who love each other, but not by idiotic game shows like “The Bachelor”? What does it say about us when we export democracy with Hellfire missiles, then restrict the right to vote here? What does it say about us when we build nuclear submarines to defend against exploding vests? What does it say about us when we think a guy who doesn’t drink, doesn’t smoke, keeps his money offshore, stubs his toe and says “H-E-double hockey sticks” and wears magical underwear can feel our pain? What does it say about us when we demand less government and more FEMA? What does it say about us when we completely forgot the colossal shit storm we were in four years ago?


The answer, my friends, is not blowing in the wind.


The answer is, “We are fucking crazy.”


It’s just a shame that Lorre has trouble sharing his feelings.


TV News Headlines – Yahoo! News



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Watch: Cancer Touches Everyone: Dogs and Humans

























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Cancer Touches Everyone: Dogs and Humans





















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Bloomberg cancels marathon amid outcry

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Apple rolls out iPad mini in Asia to shorter lines

SYDNEY (Reuters) - Apple fans lined up in several Asian cities to get their hands on the iPad mini on Friday, but the device, priced above rival gadgets from Google and Amazon.com, attracted smaller crowds than at the company's previous global rollouts.


Apple Inc's global gadget rollouts are typically high-energy affairs drawing droves of buyers who stand in line for hours. But a proliferation of comparable rival devices may have sapped some interest.


About 50 people waited for the Apple store in Sydney, Australia, to open, where in the past the line had stretched for several blocks when the company debuted new iPhones.


At the head of Friday's line was Patrick Li, who had been waiting since 4:30 am and was keen to get his hands on the 7.9-inch slate.


"It's light, easy to handle, and I'll use it to read books. It's better than the original iPad," Li said.


There were queues of 100 or more outside Apple stores in Tokyo and Seoul when the device went on sale, but when the company's flagship Hong Kong store opened staff appeared to outnumber those waiting in line.


The iPad mini marks Apple's first foray into the smaller-tablet segment, and the latest salvo in a global mobile-device war that has engulfed combatants from Internet search leader Google Inc to Web retailer Amazon.com Inc and software giant Microsoft Corp.


Microsoft's 10-inch Surface tablet, powered by the just-launched Windows 8 software, went on sale in October, while Google and Amazon now dominate sales of smaller, 7-inch multimedia tablets.


POSITIVE REVIEWS


Unveiled last week, the iPad mini has won mostly positive reviews, with criticism centering on a screen considered inferior to rivals' and a lofty price tag. The new tablet essentially replicates most of the features of its full-sized sibling, but in a smaller package.


"Well, first of all it's so thin and light and very cute - so cute!" said iPad mini customer Ten Ebihara at the Apple store in Tokyo's upscale Ginza district.


At $329 for a Wi-Fi only model, the iPad mini is a little costlier than predicted but some analysts see that as Apple's attempt to retain premium positioning.


Some investors fear the gadget will lure buyers away from Apple's $499 flagship 9.7-inch iPad, while proving ineffective in combating the threat of Amazon's $199 Kindle Fire and Google's Nexus 7, both of which are sold at or near cost.


Also on Friday, Apple rolled out its fourth-generation iPad, with the same 9.7-inch display as the previous version but with a faster A6X processor and better Wi-Fi. Both devices were going on sale in more than 30 countries.


Apple will likely sell between 1 million and 1.5 million iPad minis in the first weekend, far short of the 3 million third-generation iPads sold last March in their first weekend, according to Piper Jaffray analyst Gene Munster.


"The reason we expect fewer iPad minis compared to the 3rd Gen is because of the lack of the wireless option and newness of the smaller form factor for consumers," Munster said in a note to clients. "We believe that over time that will change."


Reviewers have applauded Apple for squeezing most of the iPad's features into a smaller package that can be comfortably manipulated with one hand.


James Vohradsky, a 20 year-old student who previously queued for 17 hours at the Sydney store to buy the iPhone 5, only stood in line for an hour and a half this time.


"I had an iPad 1 before, I kind of miss it because I sold it about a year ago. It's just more practical to have the mini because I found it a bit too big. The image is really good and it's got the fast A5 chip too," Vohradsky said.


The iPad was launched in 2010 by late Apple boss Steve Jobs and since then it has taken a big chunk out of PC sales, upending the industry and reinventing mobile computing with its apps-based ecosystem.


A smaller tablet is the first device to be added to Apple's compact portfolio under Cook, who took over from Jobs just before his death a year ago. Analysts credit Google and Amazon for influencing the decision.


Some investors worry that Apple might have lost its chief visionary with Jobs, and that new management might not be able to stay ahead of the pack as rivals innovate and encroach on its market share.


(Additional reporting by Mariko Lochridge in Tokyo, Stefanie McIntyre in Hong Kong and Miyoung Kim in Seoul; Writing by Noel Randewich and Edwin Chan in San Francisco; Editing by Phil Berlowitz and Alex Richardson)


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Songwriter Bill Dees,”Oh, Pretty Woman” co-writer, dead at 73

























LOS ANGELES (Reuters) – Singer-composer Bill Dees, best known for his songwriting collaboration with Roy Orbison on the hits “Oh, Pretty Woman” and “It’s Over,” has died at age 73 in Mountain Home, Arkansas, according to an obituary posted online by a local funeral home.


Dees, a Texas native who got his start in the 1950s with a high school band called the Five Bops, is credited with writing scores of songs in all, some recorded by such performers as Johnny Cash, Loretta Lynn and Glen Campbell.





















But Dees’ most fruitful collaboration was his work with fellow Texan Orbison, with whom he teamed up to write Orbison’s signature 1964 hit, “Oh, Pretty Woman.” which was featured years later in the soundtrack to the movie “Pretty Woman,” starring Julia Roberts and Richard Gere.


The band Van Halen also scored a hit with a cover version of “Oh, Pretty Woman.”


According to various accounts, the song’s refrain grew out of an offhand comment Dees made when Orbison’s wife, Claudette, walked into the room where the two men were writing together, and Orbison asked her if she needed any money.


Dees cracked, “Pretty woman never needs any money,” and the song took shape from there, with the bulk of the composition coming together in less than hour.


As recounted in one biography posted on Dees’ official website, Dees also contributed uncredited harmony vocals on the record.


“Oh, Pretty Woman” went to No. 1 in United States and topped the charts in Britain, as did the 1964 Orbison ballad co-written by Dees, “It’s Over,” a considerable achievement given the dominance of the Beatles and other British groups on both sides of the Atlantic at the time.


Other Orbison singles Dees co-wrote included “Born on the Wind,” “Crawling Back,” “Communication Breakdown,” “Walk On,” “Windsurfer” and “So This Is Love.”


Dees died last week, on October 24, at Mountain Home, where he had lived since 1989, according to an announcement posted on the website of the Kirby & Family Funeral Home, where a memorial service is scheduled for Saturday, November 3.


(Writing by Steve Gorman; Editing by Eric Walsh and W Simon)


Celebrity News Headlines – Yahoo! News



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Gas stations scramble in Sandy's aftermath

NEW YORK (AP) — There's plenty of gasoline in the Northeast — just not at gas stations.

In parts of New York and New Jersey, drivers lined up Thursday for hours at gas stations that were struggling to stay supplied. The power outages and flooding caused by Superstorm Sandy have forced many gas stations to close and disrupted the flow of fuel from refineries to those stations that are open.

At the same time, millions of gallons of gasoline are sitting at the ready in storage tanks, pipelines and tankers that can't unload their cargoes.

"It's like a stopped up drain," said Tom Kloza, Chief Oil Analyst at the Oil Price Information Service.

For people staying home or trying to restart a business, the scene wasn't much brighter: Millions were in the dark and many will remain so for days. As of Thursday, 4.5 million homes were without power, down from a peak of 8.5 million. The New Jersey utility Public Service Electric & Gas said it will restore power to most people in 7 to 10 days. Consolidated Edison, which serves New York City and Westchester County, said most customers will have power by Nov. 11, but some might have to wait an additional week or longer.

Superstorm Sandy found a host of ways to cripple the region's energy infrastructure. Its winds knocked down power lines and its floods swamped electrical substations that send power to entire neighborhoods. It also mangled ports that accept fuel tankers and flooded underground equipment that sends fuel through pipelines. Without power, fuel terminals can't pump gasoline onto tanker trucks, and gas stations can't pump fuel into customers' cars.

The Energy Department reported Thursday that 13 of the region's 33 fuel terminals were closed. Sections of two major pipelines that serve the area — the Colonial Pipeline and the Buckeye Pipeline — were also closed.

Thousands of gas stations in New Jersey and Long Island were closed because of a lack of power. AAA estimates that 60 percent of the stations in New Jersey are shut along with up to 70 percent of the stations in Long Island.

Thursday morning the traffic to a Hess station on 9th Avenue in New York City filled two lanes of the avenue for two city blocks. Four police officers were directing the slow parade of cars into the station.

A few blocks away, a Mobil station sat empty behind orange barricades, with a sign explaining it was out of gas.

Taxi and car service drivers were running dry — and giving up, even though demand for rides was high because of the crippled public transit system. Northside Car Service in Williamsburg, Brooklyn has 250 drivers available on a typical Thursday evening. Today they had just 20. "The gas lines are too long," said Thomas Miranda, an operator at Northside.

Betty Bethea, 59, waited nearly three hours to get to the front of the line at a Gulf station in Newark, but she brought reinforcements: Her kids were there with gas cans, and her husband was behind her in his truck.

Bethea had tried to drive to her job at a northern New Jersey Kohl's store on Thursday morning, only to find her low-fuel light on. She and her husband crisscrossed the region in search of gas and were shooed away by police at every closed station she encountered.

"It is crazy out here — people scrambling everywhere, cutting in front of people. I have never seen New Jersey like this," Bethea said.

But relief appeared to be on the way, even as the lines grew Thursday. The Environmental Protection Agency lifted requirements for low-smog gasoline, allowing deliveries of gasoline from other regions. Tanker trucks sped north from terminals in Baltimore and other points south with fuel.

A big delivery of fuel was on its way south to Boston from a Canadian refinery. Ports and terminals remained open in Connecticut, Rhode Island, and Pennsylvania, and portions of the Colonial and Buckeye pipelines are expected to re-open on Friday. Kinder Morgan Energy Partners expects to open its three terminals in New Jersey and New York over the next two days after bringing in backup generators.

And the U.S. Coast Guard opened the Port of New York and New Jersey to tankers Thursday.

Logistical problems will remain, though, for days. Barges can now visit terminals up the Hudson River and into Long Island Sound, but many of the major fuel hubs and terminals near the New York and New Jersey ports still can't offload fuel. They need to get electricity back, pump water out of flooded areas, and inspect equipment before starting operations again.

And gas stations won't be able to open up until they have power, either.

That means tanker trucks will have to travel further to deliver fuel to stations, and customers will have to drive further to find open stations.

It does not mean, however, that the region will run out of gasoline. OPIS's Kloza suspects the long lines are partly a result of panic-buying.

"This is not the Arab Oil Embargo again," he said. "There are moments when hysteria is warranted, and moments it's not. Right now, it's not."

Prices shouldn't spike like they did in the 1970s — or even as they did before Hurricane Isaac slammed the Gulf Coast this summer. There may be a short-term increase, but gas prices should resume what has been a 6-week slide. Gasoline demand is very low at this time of year, and there's enough fuel to go around — as soon as it can get around.

The national average gasoline price fell a penny to $3.51 per gallon Thursday, according to AAA, OPIS and Wright Express. Six weeks ago the price was $3.87.

Patrick DeHaan of GasBuddy.com, which collects gasoline prices from thousands of drivers, said prices weren't spiking in New York and New Jersey on Thursday. It was just a matter of finding stations that were open and had fuel.

___

Samantha Henry and Michael Rubinkam contributed to this story from Newark, N.J.

___

Follow Jonathan Fahey on Twitter at http://twitter.com/JonathanFahey .

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Mexico’s Day of Dead brings memories of missing

























MEXICO CITY (AP) — Maria Elena Salazar refuses to set out plates of her missing son’s favorite foods or orange flowers as offerings for the deceased on Mexico‘s Day of the Dead, even though she hasn’t seen him in three-and-a-half years.


The 50-year-old former teacher is convinced that Hugo Gonzalez Salazar, a university graduate in marketing who worked for a telephone company, is still alive and being forced to work for a drug cartel because of his skills.





















“The government, the authorities, they know it, that the gangs took them away to use as forced labor,” said Salazar of her then 24-year-old son, who disappeared in the northern city of Torreon in July 2009.


The Day of the Dead — when Mexicans traditionally visit the graves of dead relatives and leave offerings of flowers, food and candy skulls — is a difficult time for the families of the thousands of Mexicans who have disappeared amid a wave of drug-fueled violence.


With what activists call a mix of denial, hope and desperation, they refuse to dedicate altars on the Nov. 1-2 holiday to people often missing for years. They won’t accept any but the most certain proof of death, and sometimes reject even that.


Numbers vary on just how many people have disappeared in recent years. Mexico’s National Human Rights Commission says 24,000 people have been reported missing between 2000 and mid-2012, and that nearly 16,000 bodies remain unidentified.


But one thing is clear: just as there are households without Day of the Dead altars, there are thousands of graves of the unidentified dead scattered across the country, with no one to remember them.


An investigation conducted by the newspaper Milenio this week, involving hundreds of information requests to state and municipal governments, indicates that 24,102 unidentified bodies were buried in paupers’ or common graves in Mexican cemeteries since 2006. The number is almost certainly incomplete, since some local governments refused to provide figures, Milenio reported.


And while the number of unidentified dead probably includes some indigents, Central American migrants or dead unrelated to the drug war, it is clear that cities worst hit by the drug conflict also usually showed a corresponding bulge in the number of unidentified cadavers. For example, Mexico City, which has been relatively unscathed by drug violence, listed about one-third as many unidentified burials as the city of Veracruz, despite the fact that Mexico City’s population is about 15 times larger.


Consuelo Morales , who works with dozens of families of disappeared in the northern city of Monterrey, said that “holidays like this, that are family affairs and are very close to our culture, stir a lot of things up” for the families. But many refuse to accept the deaths of their loved ones, sometimes even after DNA testing confirms a match with a cadaver.


“They’ll say to you, ‘I’m not going to put up an altar, because they’re not dead,” Martinez noted. “Their thinking is that ‘until they prove to me that my child is dead, he is alive.”


Martinez says one family she works with at the Citizens in Support of Human Rights center had refused to accept their son was dead, even after three rounds of DNA testing and the exhumation of the remains.


“It was their son, he was very young, and he had been burned alive,” Martinez said by way of explanation.


The refusal to accept what appears inevitable may be a matter of desperation. Martinez said some families in Monterrey also believe their missing relatives are being held as virtual slaves for the cartels, even though federal prosecutors say they have never uncovered any kind of drug cartel forced-labor camp, in the six years since Mexico launched an offensive against the cartels.


But many people like Salazar believe it must be true. “Organized crime is a business, but it can’t advertise for employees openly, so it has to take them by force,” Salazar said.


While she refuses to erect an altar-like offering for her son, she does perform other rituals that mirror the Day of the Dead customs, like the one that involves scattering a trail of flower petals to the doorsteps of houses to guide spirits of the departed back home once a year.


Salazar and her family still live in the same home in Torreon, though they’d like to move, in the hopes that Hugo will return there. They pray three times a day for God to guide him home.


“We live in the same place, and we try to do the same things we used to,” said Salazar, “because he is going to come back to his place, his home, and we have to be waiting for him.”


Mistrust of officials has risen to such a point that some families may never get an answer they’ll accept.


The problem is that, with forensics procedures often sadly lacking in Mexican police forces, the dead my never be connected with the living, which is the whole point of the Mexican traditions.


“As long as the authorities don’t prove the opposite, for us they’re still alive,” Salazar said. “Let them prove it, but let us have some certainty, not just the authorities saying ‘here he is.’ We don’t the government to just give us bodies that aren’t theirs, and that has happened.”


Latin America News Headlines – Yahoo! News



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Apple's Cook fields his A-team before a wary Wall Street

SAN FRANCISCO (Reuters) - Apple Inc Chief Executive Tim Cook's new go-to management team of mostly familiar faces failed to drum up much excitement on Wall Street, driving its shares to a three-month low on Wednesday.


The world's most valuable technology company, which had faced questions about a visionary-leadership vacuum following the death of Steve Jobs, on Monday stunned investors by announcing the ouster of chief mobile software architect Scott Forstall and retail chief John Browett -- the latter after six months on the job.


Cook gave most of Forstall's responsibilities to Macintosh software chief Craig Federighi, while some parts of the job went to Internet chief Eddy Cue and celebrated designer Jony Ive.


But the loss of the 15-year veteran and Jobs's confidant Forstall, and resurgent talk about internal conflicts, exacerbated uncertainty over whether Cook and his lieutenants have what it takes to devise and market the next ground-breaking, industry-disrupting product.


Apple shares ended the day down 1.4 percent at 595.32. They have shed a tenth of their value this month -- the biggest monthly loss since late 2008, and have headed south since touching an all-time high of $705 in September.


For investors, the management upheaval from a company that usually excels at delivering positive surprises represents the latest reason for unease about the future of a company now more valuable than almost any other company in the world.


Apple undershot analysts targets in its fiscal third quarter, the second straight disappointment. Its latest Maps software was met with widespread frustration and ridicule over glaring mistakes. Sources told Reuters that Forstall and Cook disagreed over the need to publicly apologize for its maps service embarrassment.


And this month, Apple entered the small-tablet market with its iPad mini, lagging Amazon.com Inc and Google Inc despite pioneering the tablet market in 2010.


Investor concerns now center around the demand, availability and profitability of new products, including the iPad mini set to hit stores on Friday.


"The sudden departure of Scott Forstall doesn't help," said Shaw Wu, an analyst with Sterne Agee. "Now there's some uncertainty in the management."


"There appears to be some infighting, post-Steve Jobs, and looks like Cook is putting his foot down and unifying the troops."


Apple declined to comment beyond Monday's announcement.


Against that backdrop, Cook's inner circle has some convincing to do. In the wake of Forstall's exit, iTunes maestro Eddy Cue -- dubbed "Mr Fixit", the sources say -- gets his second promotion in a year, taking on an expanded portfolio of all online services, including Siri and Maps.


The affable executive with a tough negotiating streak who, according to documents revealed in court, lobbied Jobs aggressively and finally convinced the late visionary about the need for a smaller-sized tablet, has become a central figure: a versatile problem-solver for the company.


Ive, the British-born award-winning designer credited with pushing the boundaries of engineering with the iPod and iPhone, now extends his skills into the software realm with the lead on user interface.


Marketing guru Schiller continues in his role, while career engineer Mansfield canceled his retirement to stay on and lead wireless and semiconductor teams. Then there's Federighi, the self-effacing software engineer who a source told Reuters joined Apple over Forstall's initial objections, and has the nickname "Hair Force One" on Game Center.


"With a large base of approximately 60,400 full-time employees, it would be easy to conclude that the departures are not important," said Keith Bachman, analyst with BMO Capital Markets. "However, we do believe the departures are a negative, since we think Mr. Forstall in particular added value to Apple."


TEAM COOK


Few would argue with Forstall's success in leading mobile software iOS and that he deserves a lot of credit for the sale of millions of iPhones and iPads.


But despite the success, his style and direction on the software were not without critics, inside and outside.


Forstall often clashed with other executives, said a person familiar with him, adding he sometimes tended to over-promise and under-deliver on features. Now, Federighi, Ive and Cue have the opportunity to develop the look, feel and engineering of the all-important software that runs iPhones and iPads.


Cue, who rose to prominence by building and fostering iTunes and the app store, has the tough job of fixing and improving Maps, unveiled with much fanfare by Forstall in June, but it was found full of missing information and wrongly marked sites.


The Duke University alum and Blue Devils basketball fan -- he has been seen courtside with players -- is deemed the right person to accomplish this, given his track record on fixing services and products that initially don't do well.


The 23-year veteran turned around the short-lived MobileMe storage service after revamping and wrapping it into the reasonably well-received iCloud offering.


"Eddy is certainly a person who gets thrown a lot of stuff to ‘go make it work' as he's very used to dealing with partners," said a person familiar with Cue. The person said Cue was suited to fixing Maps given the need to work with partners such as TomTom and business listings provider Yelp.


Cue's affable charm and years of dealing with entertainment companies may come in handy as he also tries to improve voice-enabled digital assistant Siri. He has climbed the ladder rapidly in the past five years and was promoted to senior vice president last September, shortly after Cook took over as CEO.


Both Cue and Cook will work more closely with Federighi, who spent a decade in enterprise software before rejoining Apple in 2009, taking over Mac software after the legendary Bertrand Serlet left the company in March last year


Federighi was instrumental in bringing popular mobile features such as notifications and Facebook integration onto the latest Mac operating system Mountain Lion, which was downloaded on 3 million machines in four days.


The former CTO of business software company Ariba, now part of SAP, worked with Jobs at NeXT Computer. Federighi is a visionary in software engineering and can be as good as Jobs in strategic decisions for the product he oversees, a person who has worked with him said.


His presentation skills have been called on of late, most recently at Apple annual developers' gathering in the summer.


Then there's Ive, deemed Apple's inspirational force. Among the iconic products he has worked on are multi-hued iMac computers, the iPod music player, the iPhone and the iPad.


Forstall's departure may free Ive of certain constraints, the sources said. His exit brought to the fore a fundamental design issue -- to do or not to do digital skeuomorphic designs. Skeuomorphic designs stay true to and mimic real-life objects, such as the bookshelf in the iBooks icon, green felt in its Game Center app icon, and an analog clock depicting the time.


Forstall, who will stay on as adviser to Cook for another year, strongly believed in these designs, but his philosophy was not shared by all. His chief dissenter was Ive, who is said to prefer a more open approach, which could mean a slightly different design direction on the icons.


"There is no one else who has that kind of (design) focus on the team," the person said of Ive. "He is critical for them."


(Additional reporting by Alistair Barr; Editing by Edwin Chan and Ken Wills)

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“The Details” Review: airless all-star comedy is devilishly dull

























LOS ANGELES (TheWrap.com) – The devil is in “The Details,” but only in that this smug and airless comedy feels like 91 minutes in hell. The first few minutes promise a Rube Goldberg whirligig of bad behavior, unhappy coincidences and plain old rotten luck, but all writer-director Jacob Aaron Estes (“Mean Creek”) can deliver is a group of jerks acting like jerks.


If there were any recognizable human beings on screen, this might have delivered the sort of squirmy, uncomfortable laughs that have sustained “Curb Your Enthusiasm” through multiple seasons, but the perpetrators and victims here are all such smug, dull caricatures that none of the intended satirical barbs have anywhere to land.





















Tobey Maguire stars as Jeff, a doctor who’s seemingly got the perfect house and perfect nuclear family with his wife Nealy (Elizabeth Banks) and their young son. Unfortunately, their newly-sodded backyard attracts the attention of (metaphor alert!) raccoons. Things get worse when the couple tries expanding the house to accommodate a new child, since the noise, dust and code violations all stoke the mania of their crazy-cat-lady neighbor Lila (Laura Linney).


Over the course of the film, Jeff commits horrible acts (including cheating on his wife with two different women and accidentally poisoning one of Lila’s cats) and generous ones (donating a kidney to a friend in need), and Estes delights in showing the universe punishing and rewarding Jeff purely at random, with no connection to either his sins or his good deeds.


Estes fails, however, to write any real characters, so we have a cast of talented performers trying to breathe life into people with all the depth of chess pieces. Besides Maguire (whose tendency to recede into himself is in full effect here), Banks and Linney, there’s also Kerry Washington, Dennis Haysbert and Ray Liotta trying valiantly to be more than pegs in this plot (which is less elaborate than we’re led to believe) but ultimately they are given nothing to play, nothing to do, no one to inhabit.


Ultimately, “The Details” feels frenetic when it wants to be fast-paced, and facile when it aims for some grand statement about the randomness of existence and the bitter irony of the good falling short while the evil flourish. Rarely funny, never deep and consistently exasperating, it’ll have you cheering for the raccoons.


Movies News Headlines – Yahoo! News



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Insight: Crunching the numbers to boost odds against cancer

























FRANKFURT (Reuters) – Software engineers are moving to the fore in the war on cancer, designing programmes that sift genetic sequencing data at lightning speed and minimal cost to identify patterns in tumors that could lead to the next medical breakthrough.


Their analysis aims to pinpoint the mutations in our genetic code that drive cancers as diverse as breast, ovarian and bowel. The more precise their work is, the better the chance of developing an effective new drug.





















Ever since James Watson and Francis Crick discovered the structure of DNA in 1953, scientists have been puzzling over how genes make us who we are. The confluence of computing and medicine is accelerating the pace of genetic research.


But making sense of the swathes of data has become a logjam.


That, in turn has created an opportunity for computer geeks and tech firms such as Microsoft, SAP and Amazon.


Oncology is the largest area of therapy in the global drugs market with market researcher IMS predicting it will increase to $ 83-$ 88 billion by 2016 from $ 62 billion in 2011. Computational genomics – using computers to decipher a person’s genetic instructions and the mutations in cancerous cells – is emerging as the driver of this growth.


Life Technologies Corp and Illumina Inc are among firms developing equipment that can extract a person’s entire genetic code – their genome – from a cell sample.


The newest machines are about the size of an office printer and can sequence a genome in a day, compared with six to eight weeks a few years ago. They can read the 3.2 billion chemical “bases” that make up the human genetic code for $ 1,000, compared with $ 100,000 dollars in 2008.


Growing numbers of software engineers are needed to help make sense of all this data.


“Many labs can now generate the data but fewer people or labs have the expertise and infrastructure to analyze it – this is becoming the bottleneck,” said Gad Getz, who heads the Cancer Genome Analysis group at the Broad Institute in Boston, jointly run by MIT and Harvard.


Getz is one of a new generation of computational biologists who develop algorithms to parse data from tens of thousands of cell samples, shared with research institutes around the globe.


He and his team of 30 are trying to establish recurring patterns in the mutations and how they are linked to tumor growth. They are using some 1,200 processing units, each with 4-8 gigabytes of random access memory – about the computing power that comes with most desktop PCs.


HARVESTING KNOWLEDGE


Eli Lilly CEO John Lechleiter sees potential for progress.


“We are starting to harvest the knowledge that we gained through the sequencing of the human genome, our understanding of human genetics, disease pathways. We’ve got new tools that we can use in the laboratory to help us get to an answer much, much faster,” said Lechleiter, whose firm is co-owner of the rights to bowel cancer drug Erbitux.


Approved drugs that take genetic information into account include Amgen’s Vectibix and AstraZeneca’s Iressa. But both these drugs derive from a single mutation. Sequencing has laid bare many more mutant genes – often hundreds in any given tumor – and highlighted the need for a subtler approach to cancer treatment.


Roche, the world’s largest maker of cancer medicines, has spent several million euros on information technology for a pilot scheme examining how cancer cells in petri dishes react to new drugs. The scheme involves crunching hundreds of terabytes of gene sequences.


“It’s the first large-scale in-house sequencing project for Roche and we expect more to follow in the near future,” said Bryn Roberts, Roche’s head of informatics in drug research and early development.


Roberts said the project, which uses processing power equivalent to hundreds of high-end desktop PCs, was self contained but there were plans to draw in external data. This would require advances in cloud computing – using software and computing power from remote data centers – but Roberts said the technology would soon be available.


“The scale of the problem means the solution will be on an international collaborative scale,” he said.


OPPORTUNITIES IN CLOUDS


The trend of using cloud computing networks to allow commercial and public researchers to share cancer data is promising for the likes of IBM and Google which according to GBI Research are already established providers of cloud computing to drug makers’ research efforts.


Amazon, with its cloud computing unit AWS, said it is benefiting as life science researchers rethink how data is stored, analyzed and shared. “We are happy with the growth we are seeing,” a spokesman said, declining to provide figures.


Microsoft said it was dedicating “significant resources” to the expansion of cloud computing in the health and life sciences markets.


“Pharma R&D will be working with other technology companies, like Microsoft, in developing new algorithms, methodologies and indeed even therapies themselves,” said Les Jordan, chief technology strategist at Microsoft’s Life Sciences unit.


The world’s largest business software company SAP has teamed up with German genetic testing specialist Qiagen. They are modifying SAP database software so that certain cancer diagnostic tests, which now keep a network of super computers busy for days, can be run on a desktop PC within hours.


Genetic analysis has revealed that types of cancer, now treated as one because they are in the same organ and look the same under the microscope, are driven by different genetics.


Hans Lehrach at the Max Planck Institute for Molecular Genetics in Berlin says every single tumor should be seen as an “orphan disease”, using a term for rare illnesses that typically prompt drug regulators to make drug approval easier.


He has designed a software he describes as a virtual patient. It suggests a drug or a mix of drugs based on each tumor’s genetic fingerprint. A single case can take several days to be processed.


Lehrach, a geneticist who says he has written software code throughout his scientific career, likens his approach to that of a meteorologist who regards every day’s set of readings as unique.


Taking the analogy further, he says the convention of stratifying cancer patients is equivalent to a weather forecast based on simple rules such as ‘red sky in the morning, sailor take warning’.


At a unit of Berlin’s Charite university hospital, 20 patients left with no other treatment options for their aggressive type of skin cancer are being diagnosed based on Lehrach’s computer model.


The trial is exploratory and there are no results yet on the overall treatment success, but the project, like many others, is driven by the hope that cancer can be wrestled down by sheer computing power.


(Additional reporting by Stephanie Nebehay; editing by Janet McBride)


Medications/Drugs News Headlines – Yahoo! News



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